Merrem (meropenem) is available as a generic. Please report all side effects to the doctor or nurse. The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and the majority of adverse events were reported in neonates less than 32 weeks gestational age and critically ill at baseline, making it difficult to assess the relationship of the adverse events to Common side effects of Merrem IV include injection site pain and inflammation, rash, constipation, diarrhea, nausea, vomiting, and headache. Black or tarry stools. dehydrogenase (LDH), and bilirubin, Hematologic: increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased Probenecid may increase levels of Merrem IV by reducing its elimination through the kidneys. Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, Treatment of meningitis depends upon the cause of the infection and may include antibiotics or antiviral medications. Increased levels of meropenem in the body could increase side effects like nausea, vomiting, and headache. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Nausea and vomiting. E. coli spreads from person to person via contaminated food or Merrem I.V. Merrem IV is necessary, then supplemental anti-convulsant therapy should be What drugs interact with Merrem IV (meropenem injection)? Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate Systemic adverse events that were reported with MERREM IV occurring in greater than 1.0% of the patients were diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea (1.3%), shock (1.2%), and pruritus (1.2%). Merrem (meropenem) may make you feel weak or confused. Should I Get the Pneumonia Vaccine Every Year? Safe and effective use of Merrem IV is not established in pregnant females. leukocytosis, hypokalemia, Renal: increased creatinine and increased blood urea nitrogen (BUN). Examples of strains include: EHEC (enterohemorrhagic E. coli), ETEC (enterotoxigenic E. coli), EPEC (enteropathogenic E. coli), EIEC (enteroinvasive E. coli), EAEC (enteroadherent E. coli), and EAggEC (enteroaggregative E. coli). MERREM IV was studied in 200 neonates and infants less than 3 months of age. Merrem IV. The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and the majority of adverse events were reported in neonates less than 32 weeks gestational age and critically ill at baseline, making it difficult to assess the relationship of the adverse events to Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria. During clinical investigations, 2904 immunocompetent adult patients were treated for non-CNS infections with MERREM IV (500 mg or 1 gram every 8 hours). Amropenem (500 mg) 500mg - 1 Vial Injection (Meropenem) drug information. Meropenem can also affect your neurological (brain) function, which can cause dizziness, fainting, or seizures. In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with Merrem IV. It kills bacteria that are resistant to other antibiotics. Meropenem is used in the treatment of Severe bacterial infections. The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes. Bacterial Infections 101 Pictures Slideshow, E. coli 0157:H7 (Escherichia coli 0157:H7), E. Coli Outbreaks in Potato Salad and Wading Pool. The most common adverse events occurring in greater than 5% of the patients were: headache (7.8%), nausea (7.8%), constipation (7.0%), diarrhea (7.0%), anemia (5.5%), and pain (5.1%). In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. See additional information. Anemia If experienced, these tend to have a Less Severe expression 1. somnolence, anxiety, depression, asthenia [see WARNINGS AND PRECAUTIONS], Respiratory: respiratory disorder, dyspnea, pleural effusion, asthma, cough increased, lung edema, Skin and Appendages: urticaria, sweating, skin ulcer, Urogenital System: dysuria, kidney failure, vaginal moniliasis, urinary incontinence. Symptoms include severe abdominal pain and bloody diarrhea. Like most antibacterials, it is common to have diarrhea when taking this medicine. cold, clammy skin. hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, Side effects of Merrem include nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. Read the entire FDA prescribing information for Merrem IV (Meropenem). Pneumonia can be deadly. Terms of Use. What are the important side effects of Merrem IV (meropenem injection)? Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. There are several subtypes of the E. coli Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MEROPENEM. Laboratory changes seen in the pediatric studies, including the meningitis studies, were similar to those reported in the adult studies. Enterovirulent Escherichia coli (E. coli) are strains of related bacteria that have a strong propensity to cause gastrointestinal tract infections. Upset stomach , headache , nausea , vomiting , constipation , or diarrhea may also occur. If experienced, these tend to have a Severe expression 1. severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment) hives. severe stomach pain, diarrhea that is watery or bloody; sores or white patches in your mouth or throat (yeast infection or "thrush"); nausea, vomiting, diarrhea, constipation; Risk of Breakthrough Seizures Due to Drug Interaction with Valproic Acid [see, Clostridium difficile – associated Diarrhea [see, Development of Drug-Resistant Bacteria [see, Overgrowth of Nonsusceptible Organisms [see. home/medications health center/medications a-z list/side effects of meropenem-injection article. Co-administration of meropenem IV with valproic acid or divalproex sodium reduces serum concentrations of valproic acid potentially increasing risk of breakthrough seizures. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Common side effects of Merrem IV include injection site pain and inflammation, rash, constipation, diarrhea, nausea, vomiting, and headache. Get our free fact sheet. Symptoms and signs of E. coli infection include diarrhea, stomach cramps, and sometimes fever. Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. Safe and effective use of Merrem IV is not established in pregnant females. Shortness of breath. What are the possible side effects of meropenem? Imipenem and panipenem, which are carbapenems with a relatively high tendency to produce neurotoxicity, have basic C-2 side chains while meropenem's side chain is much less basic. The most common adverse events occurring in greater than 5% of the patients were: Adverse events with an incidence of greater than 1%, and not listed above, include: For patients with varying degrees of renal impairment, the incidence of heart Fever. Meropenem may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Pneumonia is inflammation of the lung usually caused by bacterial or viral infection (rarely, also by fungi) that causes the air sacs to fill with pus. Drug interactions of Merrem IV include valproic acid or divalproex because Merrem IV may reduce absorption of valproic acid and divalproex from the intestine and increase elimination of the drugs through the kidneys thereby reducing the levels of these drugs in the body and reducing their effectiveness. You may report side effects to FDA at 1-800-FDA-1088. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Serious adverse effects are rare. bradycardia, hypotension, syncope, Digestive System: oral moniliasis, anorexia, cholestatic jaundice/jaundice, flatulence, ileus, hepatic failure, dyspepsia, Most pneumonias are caused by bacteria and viruses, but some pneumonias are caused by inhaling toxic chemicals that damage lung tissue. What to … It is unknown if Merrem IV enters breast milk. There are five types of meningitis: viral, bacterial, fungal, parasitic, and noninfectious. Complicated Skin and Skin Structure Infections Local adverse events that were reported with Merrem IV were as follows: Systemic adverse events that were reported with Merrem IV occurring in greater than 1.0% of the patients were. Pneumonia Vaccination: Who Should Have One? In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with MERREM IV. Local adverse events that were reported with MERREM IV were as follows: Systemic adverse events that were reported with MERREM IV occurring in greater than 1.0% of the patients were Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies. Meningitis, inflammation of the meninges, symptoms and signs include neck stiffness, headache, and fever. fainting. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. valproic acid's glucuronide metabolite (VPA-g) back to valproic acid, thus diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea Probenecid (Benemid) may increase levels of meropenem by reducing its elimination through the kidneys. Meropenem and vaborbactam injection may cause side effects. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse events reported as possibly, probably, or definitely related to Merrem IV and their rates of occurrence as follows: Pediatric Patients with Bacterial Meningitis. Side effects of Merrem include: nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. Although the mechanism of this interaction is unknown, data from in vitro intestinal obstruction, Hemic/Lymphatic: anemia, hypochromic anemia, hypervolemia, Metabolic/Nutritional: peripheral edema, hypoxia, Nervous System: insomnia, agitation, delirium, confusion, dizziness, Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. Blood And Lymphatic System Disorders: agranulocytosis, neutropenia, and leukopenia; a positive direct or indirect Coombs test, and hemolytic anemia. Bacteria cannot survive without a cell wall. If administration of It should be used during pregnancy only if clearly needed. Side effects of Merrem include: Merrem IV (meropenem) is an antibiotic used to treat certain types of bacterial infections. Merrem IV (meropenem) is an antibiotic used to treat certain types of bacterial infections. Pediatric Patients with Serious Bacterial Infections (excluding Bacterial Meningitis): Merrem IV was studied in 515 pediatric patients (3 months to less than 13 years of age) with serious bacterial infections (excluding meningitis, see next section) at dosages of 10 mg/kg to 20 mg/kg every 8 hours. bradycardia, hypotension, syncope, Digestive System: oral moniliasis, anorexia, cholestatic jaundice/jaundice, flatulence, ileus, hepatic failure, dyspepsia, See additional information. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse reactions reported as possibly, probably, or definitely related to Merrem IV and their rates of occurrence as follows: In the meningitis studies, the rates of seizure activity during therapy were comparable between patients with no CNS abnormalities who received meropenem and those who received comparator agents (either cefotaxime or ceftriaxone). These are the most common side effects, but there may be others. MERREM IV was studied in 321 pediatric patients (3 months to less than 17 years of age) with meningitis at a dosage of 40 mg/kg every 8 hours. The following adverse reactions have been identified during post-approval use of Merrem IV. Infection is spread generally through contaminated food or drink. For patients with varying degrees of renal impairment, the incidence of heart failure, kidney failure, seizure and shock reported with MERREM IV, increased in patients with moderately severe renal impairment (creatinine clearance 10 to 26 mL/min) [see DOSAGE AND ADMINISTRATION,WARNINGS AND PRECAUTIONS, Use In Specific Populations and greater than 0.1% of the patients are listed below within each body system in order of decreasing frequency: Bleeding events were seen as follows: gastrointestinal hemorrhage (0.5%), melena (0.3%), epistaxis (0.2%), Swelling and redness at the injection site. E. coli can cause urinary tract and bladder infections, or lead to sepsis. Side Effects for MERREM IV (meropenem injection) are also known as adverse reactions. This is not a complete list of side effects and others may occur. Major & minor side effects for Meropenem. © Merrem IV Patient Information is supplied by Cerner Multum, Inc. and Merrem IV Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Satisfactory bacteriologic response was 80% in the meropenem group and 75% in the imipenem/cilastatin group. Merrem IV (meropenem injection) side effects list for healthcare professionals. Digestive Disorders: Common Misconceptions. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products. It is unknown if Merrem IV enters breast milk. Merrem IV prevents bacteria from forming the walls that surround them. Meningitis is inflammation of the membranes that cover the spinal cord and brain. If it affects one lung, it is termed single pneumonia. Although not all of these side effects may occur, if they do occur they may need medical attention. leukocytosis, hypokalemia, Renal: increased creatinine and increased blood urea nitrogen (BUN). A second infection may happen. The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with Our Merrem IV Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Skin And Subcutaneous Disorders: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis. The following adverse reactions have been identified during post-approval use of MERREM IV. See additional information. The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. Case reports in the literature have shown that co-administration of carbapenems, including meropenem, to patients receiving valproic acid or divalproex sodium results in a reduction in valproic acid concentrations. 6 Several studies have indicated that the most important factor governing the neurotoxicity of a carbapenem is the concentration achieved in the brain tissue. (Meropenem) side effects drug center, Pharmacy Editor: Melissa Conrad Stöppler, MD. A Skin Rash 2. In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. Visit the FDA MedWatch website or call 1-800-FDA-1088. Probenecid competes with meropenem for active tubular secretion, resulting in increased plasma concentrations of meropenem. intestinal obstruction, Hemic/Lymphatic: anemia, hypochromic anemia, hypervolemia, Metabolic/Nutritional: peripheral edema, hypoxia, Nervous System: insomnia, agitation, delirium, confusion, dizziness, seizure, nervousness, paresthesia, hallucinations, Meropenem was administered to treat Escherichia coli for 3 days through an IV in hospital - noticed loosening of stools gaseous stomach and some headaches - but … It is not known whether this drug is excreted in human milk. Laboratory changes seen in the pediatric studies, including the meningitis studies, were similar to those reported in the adult studies. Meropenem Side Effects: Common, Severe, Long Term - Drugs.com Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. In this report, we present a case of DITP caused by meropenem that was confirmed by laboratory tests. Skin And Subcutaneous Disorders: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis. The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with